Etizolam vs Alprazolam

Etizolam vs Alprazolam

Etizolam verses Alprazolam Comparison & Guide

What are Etizolam and Alprazolam?

Both Etizolam and Alprazolam are medications used in the treatment of anxiety and panic disorders. While Etizolam and Alprazolam belong to Theniodiazepine and Triazolobenzodiazepine class of medications respectively. They share their chemical structure and properties of Benzodiazepines, a class of drugs used for anxiolytic and sedative purposes. Therefore, both the drugs are referred to as Benzodiazepine analogues and derivatives.

How do they work?

Etizolam and Alprazolam affect the GABA receptors of the brain cells similarly. GABA receptors are inhibitory neuroreceptors that work on excited and overcharged nerves to produce calming effects. Etizolam starts working within 30-40 minutes after use and reaches its peak effect in 3-4 hours. It has a plasma half-life of 3.5 hours, while its active metabolite alpha-hydroxyetizolam has a half-life of over 8 hours.

Alprazolam works within 5-10 minutes of taking the tablet. It reaches its peak in the bloodstream within 1-2 hours of use. The mean plasma half-life of Alprazolam is approximately 11.2 hours. However, the range is 6-27 hours for obese individuals, with a higher range possible. Both medications are metabolized by the liver and eliminated through the kidneys through urine.

Is Etizolam better than Alprazolam?

While Etizolam and Alprazolam effectively treat anxiety, Etizolam has a broader spectrum of use. It is popularly used in the short-term treatment of insomnia and for cases of depression. Etizolam additionally is used in neurosurgeries for preventing subdural hematoma. Alprazolam is also used for the treatment of co-morbid depression and managing nausea in patients undergoing chemotherapy.

Studies have shown that Etizolam produces better results in treating depression than Alprazolam without affecting the tolerance level. It has been proved to be ten times stronger than Xanax, with added properties that prevent seizures. In short, Etizolam is a better alternative to Alprazolam. 

Note :- In UK, it is possible to Order Etizolam Online without prescription. But legally you need a valid prescription in any country. 

Why then is Alprazolam in UK still popular?

The main reason for the popularity of Alprazolam is its easy availability. Etizolam has been declared a Schedule IV medicine and even Schedule I medication in some places. Because of this, it is not readily available and is mainly ordered online. Alprazolam, in comparison, is still widely available and mostly a Schedule IV. Its use has not been banned in the USA like Etizolam, and it is available under the generic name Xanax. Its increased availability is an important cause behind its immense popularity.

Strength and safety:

Both Etizolam UK and Alprazolam are short term medications that are used in regulated doses are safe. Etizolam is available in 0.25-2mg strengths and is prescribed depending on the patient’s ailment. 0.25-1mg is used in the treatment of anxiety and insomnia. 1mg-2mg dose twice daily is used for cases of depression. Maximum intake of Etizolam should not exceed 3mg-4mg daily.

Alprazolam comes in immediate-release and extended-release strengths. While both types have the same initial dose, the maintenance dose of the medication is 3-6mg per day. The maximum quantity should not exceed 10mg daily. Despite its increased strength, Alprazolam has been proved to have comparatively less effective treatment of depression than the former. Over usage of the drug or high strength, doses can increase the risk of side effects and other life-threatening complications.

Side-effects associated with Etizolam and Alprazolam

Nausea, headaches, cramps and dizziness are some of the mild side-effects related to both medications. Serious side effects include respiratory depression, low blood pressure, memory loss, confusion, blurry vision, and the overall slowdown of reflexes. These problems usually occur on long term use of the medication.

Abrupt discontinuing or withdrawal of the medication can sometimes lead to symptoms of weight loss and irritability. This is followed by rebound insomnia and other psychotic disorders, and even seizures. Because of this, it is advisable to discontinue either medication within 12 weeks of use. Discontinuing should be done in tapering doses and avoided being done abruptly.

Precautions while using Etizolam and Alprazolam

Several precautions can be taken while using either medication. Some of the standard precautions include:

1) Initially, patients should take a test batch of the medicine to check for signs of allergies or reactions. Only if the results are satisfactory should higher doses be prescribed.

2) The drugs should take them after food with a full glass of water instead of other liquids like milk, beverages or fruit juices.

3) The tablets should not be broken or crushed but swallowed whole

4) Pregnant, lactating mothers or people with a history of Benzodiazepine reaction or addiction should avoid the medication.

5) The medicines should use it with caution in people with liver or kidney infections or impairments.

6) These medications may cause dizziness or sleepiness. Driving or operating heavy machinery should be avoided after using them.

7) Medical assistance should be given immediately on evidence of any severe side effects.

Read more about Etizolam vs lorazepam, both are from the same family. 


Both Etizolam and Alprazolam are Benzodiazepine derivatives used for psychological disorders. While Etizolam is more effective, Alprazolam has a broad base of users based on its productivity and availability. Researchers have proved their efficacy over other medications. However, the growing rate of their misuse is also a significant concern. Therefore, patients must take precautions while taking them. Always stick to the prescribed dosage to avoid any risk of drug-related complications.

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