Etizolam vs Diclazepam

Etizolam vs Diclazepam

What are Etizolam and Diclazepam?

Etizolam and Diclazepam are medications from the benzodiazepine family known for their anxiolytic, hypnotic and sedative properties. Additionally, they are used as skeletomuscular relaxants and anti-convulsant as well. Etizolam is mainly used for the treatment of anxiety, insomnia and depression. Diazepam is used as a self-treatment option for anxiety and a sleep-aid in people with sleep disorders. It is also used for self-managing benzodiazepine or other stimulant withdrawal symptoms.

How do they work?

Both the medications bind themselves to the neurotransmitters in the brain. They increase the activity of GABA receptors and work on the calcium ion transport to inhibit the overstimulated nerve impulse. Diazepam additionally decreases inhibition in the neuronal networks with lesser effects on repetitive firing. It has been shown to have a plasma protein binding (ppb) of 93.8%, which is a less lipophilic compound in comparison with other benzodiazepines whose ppb is usually 98.3%

Overall comparison

Though banned in the United States, Etizolam is considered a Schedule IV medication in the rest of the world. It is used primarily in anxiety disorders and for cases of insomnia non-responsive to other medications. Clinical trials have proved Etizolam as a better option for the treatment of depression in comparison to other benzodiazepines.

Unfortunately, Diclazepam has been approved only for research purposes, and its effectiveness is yet to be proved. Studies have shown that it can reduce conflict behaviour and improve sedation and muscle reaction. Despite being synthesized since 1960, it hasn’t been approved for therapeutic use as of now. Diazepam is considered to be a functional analogue of Diazepam.

Medically, Online Etizolam In UK has been clinically proved to be 6-8 times more effective in treating insomnia. Using Etizolam in sleep-deprived patients leads to a reduction in overall downtime along with a disturbance-free long duration of sleep. Despite having the potential to treat insomnia, Diazepam is unrecognized and thus serves no purpose to the medical community.

Strength and Half-lives

Etizolam comes in strengths of 0.25mg- 2mg doses and is usually available in tablet form. The dose of the medication depends on the disorder of the patients. For anxiety and insomnia, 0.25mg-0.5mg doses are advised twice daily. For treatment of depression, 1mg-2mg doses are required, with the total dose not exceeding more than 3mg-4mg daily. Etizolam starts working within 30-40 minutes of use and reaches its peak onset within 3-4 hours of house. It has a plasma half-life of 3.5 hours, after which it gets eliminated by the kidneys through urine and faeces. Its active metabolite alpha- Hydroxyetizolam has a half-life of over 8 hours.

Diazepam is often found as a liquid solution. It is also available in powder, tablet, blotter and pellet in 1mg and 3mg strengths. A study investigating the properties of Diclazepam has proved that 1mg of the medicine has an elimination half-life of almost 42 hours. By researching the subjects’ urine samples, it is confirmed that the drug breaks down and becomes other benzodiazepine drugs, as proved by using them.

Safety:

Etizolam use can lead to several side effects over time. The results may be as mild as headache and nausea but can be as severe as visual disturbances and mental confusion. Also, discontinuing the medication all of a sudden may lead to severe withdrawal symptoms like irritability, depression, seizures, and convulsion. It is essential to treat Etizolam as a short-term treatment option and discontinue its use within 12 weeks of use.

Diazepam was never legally approved in the first place. The NFLIS (National Forensic Laboratory Information System) has termed the medication a designer benzodiazepine. 

Illegal benzodiazepine forms known as Designer benzodiazepine are used purely for intoxication. Because of their easy availability and lower cost, their popularity has further increased over the years. The legal confusion regarding the drugs as to their schedule status further adds to the problem. Even small doses of the medication can lead to addiction.

Usually, people abusing benzodiazepine medications take Diclazepam to deal with the withdrawal symptoms. This can lead to overdosing on the drug. Nausea, diarrhoea, headaches and abdominal cramps are some of the physical side-effects of the medication. Amnesia, sleep disturbance, mental incoherence and sometimes suicidal behaviour are the psychiatric effects of the medicine. Unfortunately, abrupt quitting can lead to heatstroke or intensify panic attacks. Overdosing on the medication can result in respiratory problems, coma and even death.

Read more about Etizolam vs Alprazolam.

 Precautions:

1) Do not exceed the use of Etizolam beyond its stipulated time frame

2) Consult a physician before taking Etizolam if you are pregnant or have liver or kidney impairments.

3) Avoid taking any form of designer benzodiazepines without consulting your physician

4) On having already initiated the use of Diclazepam, do not abruptly stop its use

5) If required, opt for a medically supervised detox or enter a rehabilitation program to deal with the addiction effects of either medication.

Conclusion:

The legal use of some medications from a legal and therapeutics standpoint is a blurred line. It is important to outweigh the pros and cons before using the medicine. Moreover, the government needs to conduct more research programs and find a solution to control its abuse and overuse. Overall it is essential to spread general awareness regarding their use to prevent drug-related complications.

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